Modulation of the IL-12/IFN-γ axis by IFN-α therapy for hepatitis C
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چکیده
منابع مشابه
study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
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متن کاملThe Impact of IL-18 and IFN-γ on Severity of Malaria and Quality of Treatment
Background & Objective: In human malaria, genotype of cytokines affect immune system. The impact of genotype -137G/C in IL-18 and +874A/T in IFN-γ on the severity of malaria and the quality of treatment – as factors to form asymptomatic persons in endemic regions- has been investigated.Materials & Methods: 100 patients and 102 healthy persons were evaluated by Nested-PCR and thick blood fil...
متن کاملγ-H2AX + CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection
BACKGROUND & AIMS Age is the dominant prognostic factor influencing the natural history of hepatitis C virus (HCV) infection and treatment response. Accelerated lymphocyte telomere shortening in HCV infection correlates with adverse clinical outcomes. Critical telomere shortening generates double-stranded DNA breaks (DSB) inducing the DNA damage response, leading to replicative senescence. The ...
متن کاملبررسی پلی مورفیسم ژن های ( IFN-γ R1(-611 ، IFN-γ(2109) و( IL-12B (-1188 با بیماری سل ریوی
چکیده زمینه و هدف:. بسیاری از عوامل می توانند در پیشرفت بیماری سل دخیل باشند، اما فاکتور های ژنتیکی میزبان مهمترین نقش را در پیشرفت این بیماری دارند. یکی از این فاکتورهای ژنتیکی، پلی مورفیسم ژن‌های کد کننده ی سایتوکاین ها می باشد. مطالعات اخیر نشان می دهد که سایتو کاین هایی مانند IL-12 و IFN-γ نقش محوری را در تنظیم نوع، و میزان پاسخ های ایمنی در عفونت های مایکوباکتریومی بازی می کنند و موتاس...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2006
ISSN: 0741-5400
DOI: 10.1189/jlb.1006622